Intermediates ntawm Remazolam Benzenesulfonate (CAS No. 308242-23-1)
Synonyms:(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methylester; Methyl3-[(3S)-7-bromo-2-oxo-5-(2-pyridinyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-3-yl]propanoate; (S)-Methyl3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate; 3-[(S)-7-bromo-2-oxo-5-pyridin-2-yl-2, 3-dihydro-1H-1, 4-benzodiazepin-3-yl]-propionicacidmethylester.
CAS Nr.:308242-23-1
Molecular Formula:C18H16BrN3O3
Molecular Luj:402.24 ib
Daim ntawv thov: Pharmaceuticals, intermediates, APIs, kev cai synthesis, tshuaj
Kev siv:Intermediates ntawm Remazolam Benzenesulfonate
Qauv
Superiority:Tus neeg muag khoom zoo tshaj plaws, siab zoo, tus nqi sib tw, xa khoom sai, teb sai
Yam muaj feem:Cov tshuaj zoo
| Boiling point | 545.3 ± 50.0 ° C (Predicted) |
| Qhov ntom | 1.52 ± 0.1 g / cm3 (Kev kwv yees) |
| Kev cia khoom | Muab kaw rau hauv qhuav, Chav Kub |
| pKa | 11.15 ± 0.70 (kwv yees) |
| Tshwj xeeb specifications raws li tus neeg yuav tsum tau muaj | |
| Qhov tshwm sim | Dawb rau daj hmoov |
| Dej | 1.0% max |
| Isomer | 1.5% max |
| Purity | 9 8.0;nqi |
Kev ceev faj rau kev nyab xeeb:
Tuav nyob rau hauv qhov chaw zoo ventilated. Hnav khaub ncaws tiv thaiv zoo. Tsis txhob kov ntawm daim tawv nqaij thiab qhov muag. Tsis txhob tsim cov hmoov av thiab aerosols. Siv cov cuab yeej tsis muaj teeb meem. Tiv thaiv hluav taws los ntawm electrostatic tawm chav.
Cov xwm txheej rau kev ruaj ntseg cia, suav nrog txhua qhov tsis sib xws:
Khaws lub thawv kaw kom nruj rau hauv qhov chaw qhuav, txias thiab zoo-ventilated. Cia sib nrug ntawm cov khoom ntim khoom noj lossis cov khoom siv tsis sib xws.
Jingye muaj 86 pawg ntawm cov reactors nyob rau hauv tag nrho, uas lub ntim ntawm enamel reactor yog 69, los ntawm 50 mus rau 3000L. Tus naj npawb ntawm stainless reactors yog 18, los ntawm 50 mus rau 3000L. QC tau nruab nrog ntau pua ntawm txhua yam kev ntsuas ntsuas. Nws tuaj yeem ua tau raws li kev lag luam ntau lawm thiab kev tsom xam ntawm cov khoom. Cov khoom no yog cov khoom lag luam zoo tshaj plaws thiab tuaj yeem xa tuaj raws li cov neeg siv khoom xav tau.
Jiangsu Jingye Pharmaceutical Co., Ltd. yog yav dhau los lub npe Jintan Depei Chemical Co., Ltd. uas tau tsim nyob rau hauv 1994, thiab hloov mus rau ib tug kws tshuaj chaw tsim tshuaj paus nyob rau hauv 2016. Tom qab ob xyoos ntawm txoj kev loj hlob, Jingye Pharmaceutical tau loj hlob mus rau ib tug kws thiab kev kws tshuaj. kev lag luam sib txuas R & D, ntau lawm, ntshuam thiab xa tawm nrog ob lub koom haum nyob hauv Shanghai thiab Lianyungang.